Turbinatine, a potential key intermediate in the biosynthesis of corynanthean-type indole alkaloids.
نویسندگان
چکیده
Extraction of the leaves of Chimarrhis turbinata has led to the isolation of turbinatine (1), a new corynanthean-type indole alkaloid, besides four known indole alkaloids, strictosidine, 5alpha-carboxystrictosidine, vallesiachotamine, and isovallesiachotamine. The structural determination of 1 was based on 1D and 2D spectroscopic data. An evaluation of the DNA-damaging activities of the isolates was performed by means of a bioassay using mutant strains of Saccharomyces cerevisiae, which indicated these compounds were weakly active.
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عنوان ژورنال:
- Journal of natural products
دوره 66 7 شماره
صفحات -
تاریخ انتشار 2003